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HIV regimens are associated with neural tube defects


The prevalence of neural tube defects (NTD) was slightly higher with use of antiretroviral (ART) regimens containing dolutegravir (Tivicay—ViiV) than with nondolutegravir regimens, according to results of a birth-outcomes surveillance study published in the New England Journal of Medicine.


Zash R, et al. Neural-tube defects and antiretroviral treatment regimens in Botswana. N Engl J Med. 2019;381(9):827–40.

Raesima MM, et al. Dolutegravir use at conception — additional surveillance data from Botswana. N Engl J Med. 2019;381(9):885–7.

Havlir DV, et al. Global HIV treatment – turning headwinds to tailwinds. N Engl J Med. 2019;381(9):873–4.